The investigation of substituted amphetamines and entactogenic compounds represents a cornerstone of modern psychopharmacological and neurochemical research. Among these substances, 3,4-methylenedioxymethamphetamine—frequently encountered in pressed oral formats as MDMA tablets or ecstasy—has drawn intense academic and public health scrutiny due to its unique mechanisms of action, profound effects on monoaminergic neurotransmitters, and strict international legal controls. […]